Protective effect of Globe Artichoke (Cynara Scolymus L.) on Growing Male Rats Fed on High Fat and Fructose diet

The present study was carried out to investigate the effect of globe artichoke on high fat and fructose (HF/HFr) diet on the onset of the characteristics of the the levels of growing male. Also the possible protective effects of artichoke (AK) against (HF/HFr) diet induced-metabolic disturbances. Thirty sex male albino rats were randomly assigned into 4 groups and were fed for 6 weeks the following diets group 1 basal diet,  negative control (C) group 2 basal diet containing 20 g AK/kg diet (C+AK), group 3 high fat diet (15% beef tallow + 5% corn oil) combined with fructose (13% W/V) in drinking water (HF/HFr), group 4  HF/HFr diet containing 20 g AK/kg diet (HF/HFr+AK). HF/HFr diet induced elevated levels of blood glucose, serum TG, TC, LDL-C, liver, renal function and (NO) with a decrease in (HDL-C) and total antioxidant capacity compared to control. These effects were more pronounced in HF/HFr diet fed on. Globe artichoke reinstated most of the altered measured parameters. So, HF/HFr diet developed characteristics of metabolic syndrome in growing male rats. Artichoke were protected against some metabolic disturbances of HF/HFr diet. The inclusion of artichoke consumption has a beneficial effect in control and management of diabetes and diabetes associated complications with no risk of hypoglycemic effect.