Comparative Studies on Antioxidant and Anticancer Activities of Leaves and Fruit's Manilkara zapota (L.)

نوع المستند : المقالة الأصلية

المؤلف

Nutrition and Food Science Department, Faculty of Home Economics, Helwan University, Cairo, Egypt.

المستخلص

Manilkara zapota (L.)   (sapota), a member of the Sapotaceae family, is highly regarded for its traditional and medicinal value, being used across various cultures to treat a wide range of ailments. This study aims to comprehensively investigate the qualitative and quantitative properties, antioxidant activities, and potential anticancer effects of M. zapota extracts. Manilkara zapota (L.)   (sapota) leaves and fruit were collected from local market, then carefully dried, ground into powder, and subjected to aqueous extraction. Qualitative analysis revealed the presence of alkaloids, flavonoids, saponins, tannins, terpenoids, anthraquinones, and polyphenols. Notably, tannins were absent in M. zapota leaves extract but present in fruit extract, while glycosides were detected only in the leaves extract. Quantitative analysis showed significantly higher levels of total flavonoids and phenolics in M. zapota fruit extracts compared to leaves extract. FT-IR analysis identified the functional groups present in the extracts. Further, free radical scavenging assays, including the DPPH and reducing power assay, demonstrated superior antioxidant activity in Manilkara zapota (L.) fruit extract compared to leaves extract. Additionally, the anticancer potential against breast cancer cell lines was assessed, revealing significant antiproliferative effects in the Manilkara zapota (L.) (sapota) fruit extract. Overall, the findings highlight the strong antioxidant and anticancer properties of Manilkara zapota (L.)   fruit extract in comparison to its leaves extract.

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