Evaluation the effect of Antidiabetic activity of bitter wood (Quassia amara) and silver orache (Atriplex halimus L.) leaves powder on STZ- induced diabetes

نوع المستند : المقالة الأصلية

المؤلفون

1 Department of Nutrition and Food science, Faculty of Home Economics, Menoufia University, Egypt

2 Department of Home Economics, Faculty of Specific Education, Tanta University, Egypt

المستخلص

The condition known as diabetes is defined as one in which insulin's homeostasis of lipid and sugar digestion is incorrectly regulated. This study aimed to investigate the antidiabetic properties of bitter wood or silver orache leaves powder or their mixture on streptocetozen (STZ) induced diabetic rats.  A total of 40 rats, weighted 160± 5g, were used. And a single streptozotocin (STZ) intraperitoneal injection at 65 mg/kg body weight was administered to induce diabetic rats. Rats were randomly separated to 8 groups: Group 1, healthy rats as control negative group that given basal diet; Group2, the diabetic rats served as the positive control that just given the regular diet, groups 3-8, the diabetic rats which received the standard diet plus 2.5 and 5% of silver orache or bitter wood leaves powder individually and in combination for 8 weeks. Samples of blood were collected and biochemical markers like glucose levels, insulin, liver enzymes, renal function, white blood cells, red blood cells, hemoglobin, fructoseamine and C-peptied were measured after the experiment ended. The obtained results of data confirmed that, in evaluation to the control positive group, the examined plants (P≤0.05) dropped serum sugar, additionally enhanced kidney and liver functions. According to the findings, silver orache and bitter wood leaves powder might be considered antidiabetic agents due to consist of a variety of active phytochemical compounds. Further studies on different animal models are needed to prove these finding and detect the perfect safe active dose, duration and form that can be used.

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