Effect Of Psidium Guajava And Artemisia annua Leaves On Nephrotoxic In Experimental Rats

The current study looked at the preventive effects of aqueous extracts of Psidium guajava leaves (EEPGL) and Artemisia annua on gentamicin-induced nephrotoxicity in rats. Thirty-six male albino rats were separated into two major groups as follows: (The first core group of six rats) This primary group was fed a basal diet and served as the control group. (The second major group (30 rats): This main group was fed a basal diet and administered gentamicin (GM) intraperitoneally at a dose rate of 80 mg/kg body weight of rat for 8 consecutive days to induce nephrotoxicity. The rats in the second major group (30 rats) were then divided into  into five subgroups (each group had six rats) as follows:Group 1 was fed on B.D. and kept as the control (+ve) group.Group 2: fed on B.D. and treated with 250 mg/kg b.w. of guava leaf aqueous extract daily; Group 3: fed on B.D. and treated with 500mg/kg b.w. of guava leaf aqueous extract daily; Group 4: fed on B.D. and treated with Artemisia extract orally 100 mg/kg b.w. daily; and Group 5: fed on B.D. and treated with Artemisia extract orally 200 mg/kg b.w. daily. The current studies demonstrated that guava 500 mg/kg normalized AST, ALT, and ALP similarly to healthy control, while Artemisia 200 mg/kg exhibited comparable efficacy.Guava 500 mg/kg reduced serum urea, uric acid and creatinine, while Artemisia 200 mg/kg achieved near-normal levels of urea, uric acid and creatinine. Both Psidium guajava and Artemisia annua extracts demonstrated significant nephroprotective and hepatoprotective effects against gentamicin-induced toxicity. Higher doses (500 mg/kg guava, 200 mg/kg Artemisia) were most effective, restoring biochemical, histological, and antioxidant parameters to near-normal levels.