Impact of Bitter Orange(Citrus aurantium) Extract on Rats Suffering From Fatty Liver

 
This research aimed to examine the beneficial effects of bitter orange extract on rat suffering from fatty liver. Thirty-six male albino rat with a weight of 160 ± 5 g were randomly allocated into six groups (6 each) . The 1^st group  has been fed on the basal food (-ve control).  while 30 rats were fed on high-fat diet and fructose to trigger fatty livers and divided into a positive control group fed on basal  diet and four treated groups with (4mg/kg, 8mg/kg, 10mg/kg, and 12mg/kg) bitter orange extract for six weeks. The outcomes illustrated that every fatty liver groups managed with bitter orange extract caused by a various diminution in FI, feed effectiveness ratio and BWG. The outcomes demonstrated a significant reduction in ALP, aspartate aminotransferase, alanine aminotransferase  enzyme activity, blood urea, creatinine, and uric acid, total cholesterol, triglycerides, low-density lipoprotein and VLDL in the serum nevertheless demonstrated significant rises in values of serum high-density lipoprotein cholesterol and malondialdehyde whereas enhancing in serum glutathione for the managed groups as than the (+ve) control group. It can be recommended that the  incorporating bitter orange extract into the diet due to their hypolipidemia  and antioxidant properties, which offer a safer therapeutic approach against fatty liver and help mitigate its complications especially for those exposed to consume saturated fats and fructose for enhancing functions of kidney and liver.